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Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.
Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, Wendell SG, Delgoffe GM. Watson MJ, et al. Among authors: overacre delgoffe ae. Nature. 2021 Mar;591(7851):645-651. doi: 10.1038/s41586-020-03045-2. Epub 2021 Feb 15. Nature. 2021. PMID: 33589820 Free PMC article.
Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity.
Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA. Overacre-Delgoffe AE, et al. Cell. 2017 Jun 1;169(6):1130-1141.e11. doi: 10.1016/j.cell.2017.05.005. Epub 2017 May 25. Cell. 2017. PMID: 28552348 Free PMC article.
Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy.
Bhattacharjee A, Burr AHP, Overacre-Delgoffe AE, Tometich JT, Yang D, Huckestein BR, Linehan JL, Spencer SP, Hall JA, Harrison OJ, Morais da Fonseca D, Norton EB, Belkaid Y, Hand TW. Bhattacharjee A, et al. Among authors: overacre delgoffe ae. Immunity. 2021 Aug 10;54(8):1745-1757.e7. doi: 10.1016/j.immuni.2021.07.005. Epub 2021 Aug 3. Immunity. 2021. PMID: 34348118 Free PMC article.
You are the tumor queen, microbiome fiend, IL-17.
Jana JA, Overacre-Delgoffe AE. Jana JA, et al. Among authors: overacre delgoffe ae. Immunity. 2024 Jan 9;57(1):11-13. doi: 10.1016/j.immuni.2023.12.011. Immunity. 2024. PMID: 38198848